Correlation between the semiquantitative score of ultrasound and WOMAC OA index of knee osteoarthritis / 中国基层医药

Objective:To explore the correlation between the semiquantitative score of bone ultrasound and the WOMAC OA index in knee osteoarthritis.Methods:From March 2017 to December 2018, 118 patients with knee osteoarthritis diagnosed and treated in Taizhou Hospital of Traditional Chinese Medicine were selected in the research.The patients' bone erosion, joint effusion, synovium hyperplasia and meniscus were evaluated by ultrasound semiquantitative scoring system.Osteoarthritis index of the patients was investigated at the same time.The correlation between the semiquantitative score of myoskeletal ultrasound and WOMAC OA index in knee osteoarthritis was analyzed.Results:In 118 patients with knee osteoarthritis, the semiquantitative scores of myoskeletal ultrasound of bone erosion was (2.33±0.37)points, joint effusion was (2.05±0.26)points, synovial hyperplasia was (2.24±0.15)points, abnormal meniscus position was (1.67±0.28)points, meniscus shape and signal was (1.15±0.14)points.The WOMAC OA index scores of patients' pain was (29.52±6.68)points, stiffness was (11.43±3.78)points, dysfunction was (93.85±18.73)points, and total score was (134.80±29.19)points.The scores of bone erosion, joint effusion, synovium hyperplasia and meniscus in semiquantitative score of muscle and bone ultrasound were positively correlated with the total score of WOMAC OA index( r=0.435, 0.317, 0.429, 0.294, 0.282, all P<0.05). Conclusion:Semiquantitative score of muscle and bone ultrasound can better reflect the degree of knee joint injury, which is positively correlated with WOMAC OA index.We can use the semiquantitative score of muscle and bone ultrasound and WOMAC OA index to predict the condition of patients with knee osteoarthritis.

Advances of CLDN18.2 protein in the therapy of malignant tumors / 中国肿瘤临床

With the development of molecular biology research, targeted therapy has become the fourth effective method for the treatment of malignant tumors after surgery, radiotherapy, and chemotherapy. Unlike the traditional chemotherapeutic drugs, molecular targeted drugs possess the advantages of high specificity, definite curative effects, and less adverse effects. CLDN18.2 protein is a transmembrane protein that is highly selective and stably overexpressed during the development of various malignant tumors, especially gastrointestinal tumors, and metastases. A specific antibody against this protein, claudiximab (zolbetuximab/IMAB362), has achieved great success in recent clinical trials. Thus, CLDN18.2 protein is expected to be a safe and effective molecular target for targeted therapy in some malignancies.

Ultrasonographic evaluation of pelvic floor function in elderly patients after total hysterectomy / 中华老年医学杂志

Objective To evaluate the value of perineal pelvic ultrasonography in assessing the pelvic floor function of the elderly patients after total hysterectomy.Methods The clinical data of 56 cases of cervical cancer treated by hysterectomy in Zhejiang Taizhou Hospital from June 2014 to June 2017 were retrospectively analyzed.The results of perineal pelvic ultrasonography and various kinds of ultrasound examinations before and after surgery were analyzed.Results Among the 56 patients,31 cases(55.4％) were diagnosed as pelvic floor dysfunction after hysterectomy.Post-operation group versus pre-operation group showed that posterior urethrovesical angle in resting state was[(123.5 ± 9.3) ° vs.(90.4 ± 8.6)°,P ＜ 0.05],posterior urethrovesical angle in the Valsalva movement was [(135.7±13.5)° vs.(109.1±10.5)°,P＜0.05],urethral rotation angle was[(60.8±17.0)° vs.(27.0 ± 12.1) °,P ＜ 0.05],bladder neck descent was [(18.9 ± 8.4) mm vs.(12.5 ± 8.2) mm,P ＜ 0.05],bladder neck-symphyseal distance was[(2.7±0.5)cm vs.(2.2±0.2)cm,P＜0.05],with statistically significant differences in above parameters.Moreover,the statistically significant differences between post-operation group versus pre-operation group were found in detrusor wall thickness[(4.4±0.8)mm vs.(3.8±0.6)mm,P＜0.05],in the degree of bladder neck movement[(0.6±0.1)cm vs.(0.4±0.2) cm,P＜0.05],in the residual urinary volume[(13.1 ± 3.0) ml vs.(4.4 ± 1.3) ml,P＜0.05] and in bladder rotation angle[(12.0 ± 2.7)°vs.(4.3 ± 1.5)°,P＜0.05].Conclusions The incidence of pelvic floor dysfunction is higher after hysterectomy in patients with cervical cancer,and pelvic floor function can be accurately evaluated by perineal pelvic ultrasonography,which is worthy of clinical reference.

Clinical Observation of Vitamin C with Large Dose Combined with Diphosphate in the Treatment of Myocar-dial Injury after Neonatal Asphyxia / 中国药房

OBJECTIVE:To observe the clinical efficacy and safety of vitamin C with large dose combined with diphosphate in the treatment of myocardial injury after neonatal asphyxia and the effects on creatine kinase isoenzyme (CK-MB) level. METH-ODS:Totally 76 children with myocardial injury after neonatal asphyxia were randomly divided into control group and observation group. Control group was given routine treatment,including oxygen inhalation,sedation,cardiotonic,Danshen injection and ener-gy mixture,etc. Based on the treatment of control group,the observation group was added diphosphate 100-150 mg/(kg·d),iv infu-sion,qd;and vitamin C 250 mg/(kg·d)adding into 10%glucose injection 20 ml,iv infusion,qd. 10 d was a course. The clinical ef-ficacy,cardiac troponin T(cTnI),CK-MB level and incidence of adverse reactions before and after treatment were observed. RE-SULTS:The total effective rate in observation group was significantly higher than control group,with significant difference(P<0.05). After treatment,the cTnI and CK-MB level in 2 groups were significantly lower than before,and observation group was low-er than control group,with significant differences (P<0.05). There were no adverse reactions in 2 groups during the treatment. CONCLUSIONS:Based on the routine treatment,Vitamin C with large dose combined with diphosphate has good efficacy in the treatment of myocardial injury after neonatal asphyxia and can effectively reduce the CK-MB level,with good safety.

Combined drug sensitivity test of 50 strains of extensively drug-resistant Acinetobacter baumannii / 南方医科大学学报

<p><b>OBJECTIVE</b>To study the in vitro antibacterial activity of meropenem combined with doxycycline, ciprofloxacin, sulbactam or cefoperazone/sulbactam against clinically isolated extensively drug-resistant Acinetobacter baumannii (XDRAB).</p><p><b>METHODS</b>Using a checker board synergy design, the minimal inhibitory concentration (MIC) of antibiotics against 50 isolates of XDRAB was determined by broth microdilution antifungal susceptibility test. The fractional inhibitory concentration (FIC) index was calculated to determine the combined effect of the antibiotics.</p><p><b>RESULTS</b>Meropenem showed significantly reduced MIC50 and enhanced antimicrobial activities when combined with doxycycline, sulbactam or cefoperazone/sulbactam. The FIC results suggested that the main actions of doxycycline, sulbactam, and cefoperazone/sulbactam were synergistic (38%, 26%, and 10%, respectively) and addictive (62%, 74%, and 90%, respectively) without indifferent or antagonistic effects. The main actions of meropenem combined with ciprofloxacin were additive (56%) and indifference (44%) with synergistic and antagonistic effects.</p><p><b>CONCLUSION</b>Meropenem combined with doxycycline, sulbactam or cefoperazone/sulbactam shows excellent activity against clinical isolates of XDRAB.</p>